Post Infection Studies
Bacterial superinfections among persons with coronavirus disease 2019:A comprehensive review of data from postmortem studies
On a post-mortum report, 32% of COVID deaths were associated with bacterial superinfection.
Infection Studies
COVID-19 Rates Increased Where In-Person College Classes Were Held
Universities with in person teaching had a negative impact on community spread of COVID compared to universities who went virtual.
Virus Behavior Studies
Emergence of a Novel SARS-CoV-2 Variant in Southern California
New variant identified in California - CAL.2C
Infection Studies
Science Brief: Transmission of SARS-CoV-2 in K-12 schools
A bulleted summary report on COVID transmission in K-12.
Guidance
Maximizing Fit for Cloth and Medical Procedure Masks to Improve Performance and Reduce SARS-CoV-2 Transmission and Exposure, 2021
Double masking (cloth mask over medical mask) improves cough particle blockage from 50% to 85%.
Treatment Studies
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19
Vitamin D administration during hospitalization had no impact on hospital length of stay in COVID patients.
Infection Studies
Effect of the new SARS-CoV-2 variant B.1.1.7 on children and young people
The UK variant strain B117 does not appear to lead to more severe disease in children and young adults during […]
Medical Opinions
Delayed Second Dose versus Standard Regimen for Covid-19 Vaccination
An interesting vignette on whether a second dose of mRNA vaccine should be delayed or not.
Treatment Studies
Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study
COVID patients who received prophylactic anticoagulation on admission had 27% decreased 30-day mortality rates.
Treatment Studies
Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021
Report of 18 Million doses of mRNA vaccines that had been administered by early February, and only 66 reported cases […]
Treatment Studies
The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial
Ivermectin decreases viral load, but at least for now there is no evidence that makes a difference clinically.
Post Infection Studies
Epidemiology of post-COVID syndrome following hospitalisation with coronavirus: a retrospective cohort study
Individuals discharged from hospital following COVID-19 face elevated rates of multi-organ dysfunction compared with background levels, and the increase in […]
Infection Studies
UK Biobank SARS-CoV-2 Serology Study
Study reports that 87% of patients with COVID-19 remained seropositive for at least six months after infection.
Guidance
It Is Time to Address Airborne Transmission of Coronavirus Disease 2019 (COVID-19)
CID statement on potential for airborne spread of coronavirus and need for increased awareness.
Infection Studies
Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France
Patients chronically treated with ACEI/ARB who have severe COVID-19 are at increased risk of acute kidney injury. In these patients, […]
Guidance
Fit-failure rate associated with simulated reuse and extended use of N95 respirators assessed by a quantitative fit test
High N95 fit failure rates were recorded after repeated donning (at 1 and 3 hours of use) and extended use […]
Vaccine Trials
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
AstraZeneca is safe and total effectivity is 70% (90% if low dose followed by standard dose) for wild type virus. […]
Vaccine Trials
Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia
The Russian vaccine Sputnik V has been shown to be safe and 91% effective.
Infection Studies
COVID-19 Outcomes Among Persons Living With or Without Diagnosed HIV Infection in New York State
HIV positive patients are at higher risk of being hospitalized and have higher mortality if they are COVID positive.
Treatment Studies
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
In this interim analysis, the REGN-COV2 antibody cocktail reduced viral load, with a greater effect in patients whose immune response […]
Treatment Studies
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19
In this study, the risk of death from COVID-19 decreased with high titers of convalescent plasma administration.
Guidance
Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19
On April 11, 2020, IDSA released online initial treatment recommendations and narrative summaries of other treatments under evaluation. Since that […]
Infection Studies
SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis
Although SARS-CoV-2 RNA shedding in respiratory and stool samples can be prolonged, the duration of viable virus is relatively short-lived […]
Diagnostic Studies
Delirium in Older Patients With COVID-19 Presenting to the Emergency Department
Delirium can be the only presenting symptoms in up to 25% of elderly patients presenting to an emergency department.
Infection Studies
Glycemic control before admission is an important determinant of prognosis in patients with coronavirus disease 2019
Glycated hemoglobin (HbA1c) was an independent risk factor for poor outcomes in coronavirus disease 2019 patients. Severe pulmonary infection and […]
Guidance
Eye Protection for Patients With COVID-19 Undergoing Prolonged Prone-Position Ventilation
Prolonged prone positioning of patients with COVID-19 can be associated with elevated intraocular pressure from periorbital edema, direct compression on […]
Infection Studies
Assessment of 135 794 Pediatric Patients Tested for Severe Acute Respiratory Syndrome Coronavirus 2 Across the United States
This study suggests that for most pediatric patients, the risk of SARS-CoV-2 infection appears low, but higher concern may be […]
Guidance
Diagnosis, Management, and Pathophysiology of Arterial and Venous Thrombosis in COVID-19
Arterial and venous thrombosis are common in COVID-19, especially in critically ill patients. Thromboprophylaxis should be considered for all hospitalized […]
Treatment Studies
Remdesivir for 5 or 10 Days in Patients with Severe Covid-19
In patients with severe COVID-19 not requiring mechanical ventilation, our trial did not show a significant difference between a 5-day […]
Treatment Studies
A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
No significant differences were observed in clinical status or overall mortality between patients treated with convalescent plasma and those who […]
Infection Studies
Clinical Presentation and Outcomes of Severe Acute Respiratory Syndrome Coronavirus 2–Related Encephalitis: The ENCOVID Multicenter Study
SARS-CoV-2 infection is associated with a wide spectrum of encephalitis characterized by different clinical presentation, response to treatment, and outcomes.
Post Infection Studies
Risk Factors and Outcomes of Hospitalized Patients With Severe Coronavirus Disease 2019 (COVID-19) and Secondary Bloodstream Infections: A Multicenter Case-Control Study
Secondary bloodstream infections / bacteremia have higher in-hospital mortality in patients with COVID.
Infection Studies
Pulmonary Fungal Infections Affect Patients With COVID-19
Increased incidence of pulmonary aspergillus in COVID patients.
Guidance
Filtration Efficiency of Face Masks Used by the Public During the COVID-19 Pandemic
Filtration efficacy of different types of face masks. Regular cloth masks may be as good, if not better, than some […]
Treatment Studies
An EUA for Bamlanivimab—A Monoclonal Antibody for COVID-19
The investigational IV monoclonal antibody bamlanivimab (LY-CoV555) has been granted an Emergency Use Authorization (EUA) from the FDA based on […]
Treatment Studies
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
The use of remdesivir and barticinib had improved mortality compared to control group.
Vaccine Trials
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Data on safety for Pfizer vaccine.
Treatment Studies
Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with COVID-19, as indicated by […]
Treatment Studies
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19
Retrospective study demonstrating lower risk of death within 30 days with high titer convalescent plasma administration.
Treatment Studies
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults
Early infusions of convalescent plasma can provide a bridge to recovery for at-risk patients until vaccines become widely available.
Treatment Studies
Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
Randomized Controlled Trial (RCT) demonstrating that in hospitalized patients with COVID-19 pneumonia who were not receiving mechanical ventilation, tocilizumab reduced […]
Vaccine Trials
Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine
Phase 1 and 2 interim results demonstrate safety and adequate immunogenicity by Johnson & Johnson vaccine. Phase 3 results pending.
Diagnostic Studies
Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2: A Systematic Review and Meta-analysis
Meta-analysis demonstrating that saliva PCR accuracy is similar to that of nasopharyngeal swab PCR, especially in the ambulatory setting.
Post Infection Studies
Evaluation for Myocarditis in Competitive Student Athletes Recovering From Coronavirus Disease 2019 With Cardiac Magnetic Resonance Imaging
Case series demonstrating low prevalence of myocarditis in student athletes 2 weeks after being diagnosed with COVID (1.4%).
Infection Studies
Infectivity of Healthcare Workers Diagnosed with SARS-CoV-2 Infection Approximately 2 weeks after Onset of Symptoms: a Cross-Sectional Study
Infectivity is resolved in nearly all Health Care Workers (HCWs) approximately 2 weeks after symptom onset as demonstrated by viral […]
Vaccine Trials
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
Pfizer vaccine phase 1 report - recent news of 90% immunogenicity came from the phase 3 trial results with 44,000 […]
Guidance
Return to Play for Athletes After Coronavirus Disease 2019 Infection—Making High-Stakes Recommendations as Data Evolve
Data summary with regards to return to play guidelines for athletes after COVID-19.
Infection Studies
Health Care Worker SARS-CoV-2 Infection Is Flying Under the Radar
Report about Health Care Worker COVID-19 positivity. We must remain vigilant with PPE use and frontline providers' vulnerability.
Guidance
Elective Surgery during the Covid-19 Pandemic
Case vignette in NEJM highlighting how to navigate elective surgeries during second wave.
Treatment Studies
“Solidarity” clinical trial for COVID-19 treatments
All 4 treatments evaluated (remdesivir, hydroxychloroquine, lopinavir/ritonavir and interferon) had little or no effect on overall mortality, initiation of ventilation […]
Vaccine Trials
SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
Eli Lilly’s neutralizing antibody reports statistically significant decrease in viral load compared to placebo.
Treatment Studies
Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019
Ivermectin led to decreased mortality (15% vs 25%) when compared to placebo for COVID-19.
Virus Behavior Studies
Telework Before Illness Onset Among Symptomatic Adults Aged ≥18 Years With and Without COVID-19 in 11 Outpatient Health Care Facilities — United States, July 2020
Prior to COVID-19 diagnosis, patients were more likely to report exclusively going to an office or school setting.
Treatment Studies
Comparative Survival Analysis of Immunomodulatory Therapy for Coronavirus Disease 2019 Cytokine Storm
Tocilizumab and steroids demonstrated lower mortality compared to standard of care as well as steroid therapy alone.
Treatment Studies
Statin Use and In‐Hospital Mortality in Patients With Diabetes Mellitus and COVID‐19
Statin use in diabetic patients with COVID 19 resulted in decreased in-hospital mortality.
Treatment Studies
Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID)
Therapeutic enoxaparin improves gas exchange and decreases the need for mechanical ventilation in severe COVID–19.